Purpose: In the present study the incompatibility of FLM (fluvoxamine) with lactose in\nsolid state mixtures was investigated. The compatibility was evaluated using different\nphysicochemical methods such as differential scanning calorimetry (DSC), Fouriertransform\ninfrared (FTIR) spectroscopy and mass spectrometry.\nMethods: Non-Isothermally stressed physical mixtures were used to calculate the solidââ?¬â??\nstate kinetic parameters. Different thermal models such as Friedman, Flynnââ?¬â??Wallââ?¬â??Ozawa\n(FWO) and Kissingerââ?¬â??Akahiraââ?¬â??Sunose (KAS) were used for the characterization of the\ndrug-excipient interaction.\nResults: Overall, the incompatibility of FLM with lactose as a reducing carbohydrate was\nsuccessfully evaluated and the activation energy of this interaction was calculated.\nConclusion: In this research the lactose and FLM Maillard interaction was proved using\nphysicochemical techniques including DSC and FTIR. It was shown that DSC- based\nkinetic analysis provides fast and versatile kinetic comparison of Arrhenius activation\nenergies for different pharmaceutical samples.
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